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Joy Saves logo with pink ribbon and green peas.

We're learning SoySaves.

 A pooled analysis of 9,514 women published in the American Journal of Clinical Nutrition found that women who consumed the most soy were 25% less likely to see their breast cancer return compared to those who avoided it. 


 And an analysis of 14 separate studies showed that an increased intake of soy resulted in a 26% reduction in prostate cancer risk for men. 

Soy is such a big deal, it's now playing in theaters . . .

Only 28% of women know that healthful foods can reduce the risk of breast cancer. That’s why tennis legend Venus Williams and renowned breast cancer surgeon Kristi Funk, MD, are partnering with the Physicians Committee for Responsible Medicine (PCRM) and is now showing throughout October at AMC Theatres around the country—to share the cancer-fighting power of a plant-based diet, including soy specifically. 

it's featured by leading cancer researchers as beneficial

The American Institute for Cancer Research (AICR) shares, "Soy foods are safe for women and provide fiber, a cancer-fighter."

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it's featured by leading medical teams and nutritionists,

 Researcher Mark Messina, PhD,  joins "The Weight Loss Champion" Chuck Carroll to clear up the biggest myths surrounding soy in this recent podcast and video hosted by PCRM.  

Get Started

Additional References

  1. Wu AH, Yu MC, Tseng CC, Pike MC. Epidemiology of soy exposures and breast cancer risk. Br J Cancer. 2008;98:9-14. doi:10.1038/sj.bjc.6604145
  2. Xie  Q, Chen ML, Qin Y, et al. Isoflavone consumption and risk of breast  cancer: a dose-response meta-analysis of observational studies. Asia Pac J Clin Nutr. 2013;22:118-127. doi:10.6133/apjcn.2013.22.1.16
  3. Chen  M, Rao Y, Zheng Y, et al. Association between soy isoflavone intake and  breast cancer risk for pre- and post-menopausal women: a meta-analysis  of epidemiological studies. PLoS ONE. 2014;9:e89288-e89298. doi:10.1371/journal.pone.0089288
  4. Korde LA, Wu AH, Fears T, et al. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev. 2009;18:1050-1059. doi:10.1158/1055-9965.EPI-08-0405
  5. Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev. 2001;10(5):483-488.
  6. Lee  SA, Shu XO, Li H, et al. Adolescent and adult soy food intake and  breast cancer risk: results from the Shanghai Women's Health Study. Am J Clin Nutr. 2009;89(6):1920-1926. doi:10.3945/ajcn.2008.27361
  7. Zhang  FF, Haslam DE, Terry MB, et al. Dietary isoflavone intake and all-cause  mortality in breast cancer survivors: The Breast Cancer Family  Registry. Cancer. 2017;123(11):2070-2079. doi:10.1002/cncr.30615
  8. Caan BJ, Natarajan L, Parker B, et al. Soy food consumption and breast cancer prognosis. Cancer Epidemiol Biomarkers Prev. 2011;20:854- 858. doi:10.1158/1055-9965.EPI-10-1041
  9. Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA. 2009;302:2437-2443. doi:10.1001/jama.2009.1783
  10. Magee PJ, Rowland I. Soy products in the management of breast cancer. Curr Opin Clin Nutr Metab Care. 2012;15:586-591. doi:10.1097/MCO.0b013e328359156f
  11. Guha  N, Kwan ML, Quesenberry CP Jr, Weltzien EK, Castillo AL, Caan BJ. Soy  isoflavones and risk of cancer recurrence in a cohort of breast cancer  survivors: The Life After Cancer Epidemiology study. Breast Cancer Res Treat. 2009;118:395-405. doi:10.1007/s10549-009-0321-5
  12. Nechuta  SJ, Caan BJ, Chen WY, et al. Soy food intake after diagnosis of breast  cancer and survival: an in-depth analysis of combined evidence from  cohort studies of US and Chinese women. Am J Clin Nutr. 2012;96:123-132. doi:10.3945/ajcn.112.035972
  13. Messina MJ, Loprinzi CL. Soy for breast cancer survivors: a critical review of the literature. J Nutr. 2001;131(11 Suppl):3095S-3108S. doi:10.1093/jn/131.11.3095S
  14. Nechuta  SJ, Caan BJ, Chen WY, et al. Soy food intake after diagnosis of breast  cancer and survival: an in-depth analysis of combined evidence from  cohort studies of US and Chinese women. Am J Clin Nutr. 2012;96:123-132. doi:10.3945/ajcn.112.035972
  15. Kang  X, Zhang Q, Wang S, Huang X, Jin S. Effect of soy isoflavones on breast  cancer recurrence and death for patients receiving adjuvant endocrine  therapy. CMAJ. 2010;182:1857-1862. doi:10.1503/cmaj.091298
  16. Badger TM, Ronis MJ, Simmen RC, Simmen FA. Soy protein isolate and protection against cancer. J Am Coll Nutr. 2005;24:146S-149S. doi:10.1080/07315724.2005.10719456
  17. Yang G, Shu XO, Li HL, et al. Prediagnosis soy food consumption and lung cancer survival in women. J Clin Oncol. 2013;31:1548-1553. doi:10.1200/JCO.2012.43.0942
  18. Myung  SK, Ju W, Choi HJ, Kim SC; Korean Meta-Analysis (KORMA) Study Group.  Soy intake and risk of endocrine-related gynaecological cancer: a  meta-analysis. BJOG. 2009;116:1697-1705. doi:10.1111/j.1471-0528.2009.02322.x
  19. Schimazu T, Inoue M, Sasazuki S, et al. Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan. Am J Clin Nutr. 2010;91:722-728. doi:10.3945/ajcn.2009.28161
  20. Barnard  ND, Kahleova H, Holtz DN, et al. A dietary intervention for vasomotor  symptoms of menopause: a randomized, controlled trial. Menopause. 2023;30(1):80-87. doi:10.1097/GME.0000000000002080
  21. Kahleova  H, Holtz DN, Strom N, et al. A dietary intervention for postmenopausal  hot flashes: a potential role of gut microbiome. An exploratory  analysis. Complement Ther Med. 2023;79:103002. doi:10.1016/j.ctim.2023.103002
  22. Mitchell  JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Effect of a  phytoestrogen food supplement on reproductive health in normal males. Clin Sci (Lond). 2001;100:613-618.
  23. Kurzer MS. Hormonal effects of soy in premenopausal women and men. J Nutr. 2002;132:570S-573S. doi:10.1093/jn/132.3.570S
  24. Strom  BL, Schinnar R, Ziegler EE, et al. Exposure to soy-based formula in  infancy and endocrinological and reproductive outcomes in young  adulthood. JAMA. 2001;286:807-814. doi:10.1001/jama.286.7.807
  25. Segovia-Siapco  G, Pribis P, Messina M, Oda K, Sabaté J. Is soy intake related to age  at onset of menarche? A cross-sectional study among adolescents with a  wide range of soy food consumption. Nutr J. 2014;13:54-63. doi:10.1186/1475-2891-13-54
  26. Hamilton-Reeves  JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Clinical  studies show no effects of soy protein or isoflavones on reproductive  hormones in men: results of a meta-analysis. Fertil Steril. 2010;94:997-1007. doi:10.1016/j.fertnstert.2009.04.038
  27. Yan L, Spitznagel EL. Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr. 2009;89:1155-1163. doi:10.3945/ajcn.2008.27029
  28. Hwang  YW, Kim SY, Jee SH, Kim YN, Nam CM. Soy food consumption and risk of  prostate cancer: a meta-analysis of observational studies. Nutr Cancer. 2009;61:598-606. doi:10.1080/01635580902825639
  29. Nagata  C, Takatsuka N, Kawakami N, Shimizu H. Soy product intake and  premenopausal hysterectomy in a follow-up study of Japanese women. Eur J Clin Nutr. 2001;55:773-777. doi:10.1038/sj.ejcn.1601223
  30. Atkinson  C, Lampe JW, Scholes D, Chen C, Wähälä K, Schwartz SM. Lignan and  isoflavone excretion in relation to uterine fibroids: a case-control  study of young to middle-aged women in the United States. Am J Clin Nutr. 2006;84(3):587-93. doi:10.1093/ajcn/84.3.587
  31. Atkinson  C, Lampe JW, Scholes D, Chen C, Wahala K, Schwartz SM. Lignan and  isoflavone excretion in relation to uterine fibroids: a case-control  study of young to middle-aged women in the United States. Am J Clin Nutr. 2006;84:587-593. doi:10.1093/ajcn/84.3.587
  32. Messina  M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid  function in healthy adults and hypothyroid patients: a review of the  relevant literature. Thyroid. 2006;16:249-258. doi:10.1089/thy.2006.16.249
  33. Divi RL, Chang HC, Doerge DR. Anti-thyroid isoflavones from soybean: Isolation, characterization, and mechanisms of action. Biochem Pharmacol. 1997;54:1087-1096. doi:10.1016/s0006-2952(97)00301-8
  34. Wu SH, Shu XO, Chow WH, et al. Soy food intake and circulating levels of inflammatory markers in Chinese Women. J Acad Nutr Diet. 2012;112:996-1004. doi:10.1016/j.jand.2012.04.001
  35. Taku  K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones  lower serum total and LDL cholesterol in humans: a meta-analysis of 11  randomized controlled trials [published correction appears in Am J Clin  Nutr. 2007 Sep;86(3):809]. Am J Clin Nutr. 2007;85(4):1148-1156. doi:10.1093/ajcn/85.4.1148
  36. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr. 2005;81(2):397-408. doi:10.1093/ajcn.81.2.397
  37. Li  SS, Blanco Mejia S, Lytvyn L, et al. Effect of plant protein on blood  lipids: a systematic review and meta-analysis of randomized controlled  trials. J Am Heart Assoc. 2017;6:E1-E51. doi:10.1161/JAHA.117.006659
  38. Koh  WP, Wu AH, Wang R, et al. Gender-specific associations between soy and  risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol. 2009;170:901-909. doi:10.1093/aje/kwp220
  39. Zhang  X, Shu XO, Li H, et al. Prospective cohort study of soy food  consumption and risk of bone fracture among postmenopausal women. Arch Intern Med. 2005;165:1890-1895. doi:10.1001/archinte.165.16.1890
  40. Messina  M, Sievenpiper JL, Williamson P, Kiel J, Erdman JW. Perspective:  soy-based meat and dairy alternatives, despite classification as  ultra-processed foods, deliver high-quality nutrition on par with  unprocessed or minimally processed animal-based counterparts. Adv Nutr. 2022;13(3):726-738. doi:10.1093/advances/nmac026

as noted by the Physicians Committee for Responsible Medicine,

"New research addresses myths surrounding soy intake in an article published in Critical Reviews in Food Science and Nutrition.  The authors note that concerns over the safety of isoflavones,  phytoestrogens found in soy products, were largely based on nonhuman  animal studies that did not reflect human biology. Researchers reviewed  417 reports based on human data on isoflavone intake and  endocrine-related health outcomes. Evidence suggests isoflavone intake  does not adversely affect thyroid function, estrogen levels, ovulation  in women, or semen levels in men. These publications also showed no  negative effects in children. These results suggest neither isoflavones  nor soy foods should be classified as endocrine disruptors associated  with disease and adverse health outcomes. Soy products are actually  associated with reduced risk of breast and prostate cancer."

more on soy by PCRM

Many of our leading causes of illness like cancer, heart disease and type 2 diabetes are actually preventable and in some cases reversible through the foods we eat.  Join us as we discover in leading science and medicine how we're actually Growing the Cure locally in South Carolina.

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